The presence of alpha and beta radionuclides in tobacco and tobacco products is a frequently discussed issue. However, any information in publications about them and their presence in tobacco products is too scarce. World Healthcare Organization monitors the influence of tobacco smoking on human health. In 2003, a Framework Convention on Tobacco Control was accepted with the aim to protect human health, which was signed by 179 countries, including Bulgaria. The first debates on the presence of radionuclides in tobacco products are raised in Moscow in 2014. These were instigated by data on the findings of polonium-210, reported by USA and Russia. The aim of the report is to outline a metholdology to detect the presence of beta-active radionuclides in tobacco and its products.